AA00061 ----VLFHHLNLHIRAGDFVQIEGNNG--IGKTSLLRIIAG--LATPL---EG--------

AA00207a ---VKALSNAGLSVYAGHAMALMGENG--TGKSTLMKVLTG--IYDK---DTG--------

AA00207b ------VHDVSFALRSGEILSISGLMG--TGRSELMKVLYG--ALPRE---SG--------

AA00415 -KKLTALDNVSLDIPKGYICGVIGASG--AGKSTLIRCVNL--LEKPT---MG--------

AA00700 ----VVIDNLDLTIKRGTMVTLLGPSG--CGKTTVLRLVAG--LENPT---SG--------

AA00751a ---VKALDQANLTVRSHSVHALMG-----AGKSTLLKCLFG--IYAK---DEGVE------

AA00751b ----PSIQDVSFDLRKGEILGIAGLVG--AKRTDVVEAIFG--VRELK---SG--------

AA00799 ----IIVQDLSLDFPHNQVIALIGPNG--CGKSTTLKAIAR--LLKPR---TGKITHHGKD---

AA00858 ----QALFDINLTADDGDVLVLLGPSG--AGKSTLIRTLNL--LEVPQ---SG--------

AA00933 ---VTVLDDIHLDIRQGEVLCLIGENG--AGKSTLCKIIAG--IYHC---DEGSDRKY---

AA00934 -------------------------------------------------------------

AA01051 ----HVLHDISLQLNSGEILFLLGPSG--CGKTTLLRAIAG--FEQPD---SG--------

AA01456a ---VVALNNISISLEKAEILSLCGENG--SGKSTLMKVLCG--IYPFGD-YEGPHT-----

AA01456b --HIKRVSNASFTLHKGEILGVAGLVG--SGRTEMVQCIFG--SYPGK---HEG-K-----

AA01524 ----QVLKGIDFQIQKGEMVAMLGPSG--SGKTTFLRCLNL--LERAE---QG--------

AA01645 ----KVLQDFNLSFQKHKFTTLLGASG--CGKTTILRLIAG--LEEPD---KG--------

AA01656 ----HISKDINLDIEEGEFVVFVGPSG--CGKSTLLRMIAG--LEDIT---TG--------

AA01684 ----GILRNISLSVEAGECVAIVGESG--SGKTTLLNAIAG--Y-IDY---AG--------

AA01685 ---DLTTHALGLDDVPARILFKRKNTGRVAGVSIAEKLLRKLDVQVKVHIADG--------

AA01779 ----NLSLQAKLEIPSQGVTALFGLSG--SGKSSLINLISG--LINPD---EG--------

AA01824 ----TILNNINLTIPNGGITALIGANG--AGKSTLLSLIAR--LNPIQ---QG--------

AA01867 ----ALPMEFDLQVAAGELVAMVGPSG--AGKSTLLNFIAG--FVLPT---RGEIWLNGAFL--------

AA01947 ---------------------------------------------------PL-----------------

AA02152 ----ILVNNINFRLQEKQICCLLGANG--AGKSTFLKTLLG--LQAPL---QGKRY-----

AA02324 ----IIYHDLNLRVPRDKITAIMGPSG--IGKTTLLKLIGG--QLMPS---EG--------

AA02353 ---QHAVQTLNLTIYQGEFFVLVGGSG--SGKSTTLRMINA--LTEPT---DG--------

AA02718 ----TIIKAFNLTINNGEFLTILGPSG--CGKTTVLRLLAG--LEELD---SG--------

AA02786a ---VKALDGINLRVKRGSVHALMGENG--AGKSTLMKVLYG--IYIP---DDGPA------

AA02786b -----KYQDINFAVRKGEIFGIAGLVG--AGRSEIVEGLFG--YKPAD---SGGEK-----

AA02898 --IVTAVNDLNFTLDAGHTLGIVGESG--SGKSQTAFALMG--LLAPNGEVSGEVQ-----

AA02899 --TLKAVKDVSFKLYAGETLGVVGESG--CGKSTLARAIIG--LVEAS---EGGKD-----

AA00591 -LGKTLIKDLNLTLPQGHSLLIQGQSG--VGKTTLLRTVAG--LWLYA---QGQEQDW---

AA01393 --VKPLLTHFNLTIKPGEKVGLIGRSG--AGKSTIVNLLLR--FYEAQ---QGGVK-----

AA01422 ----PALQGLSFHLPAGSMTYLVGHSG--AGKSTLLKLIMG--MERAN---GG--------

AA01509 --EKPAINGLTLSIQPKQLTVFVGKSG--CGKSTLVSLLMG--FYQAQ---QGGSN-----

AA01510 ---EQILSDVNLHINKGEILGIHGRSG--SGKSTLLKLIMR--FYDPQ---QGGNN-----

AA01555a ----TLLENANATINPGQKVGLVGKNG--CGKSSLFALLKN--AEGGE---MS--------

AA01555b KSAVEILSKIKLNLVPGSRIGLLGKNG--AGKSTLIKLLAG--EIAPT---GG--------

AA01556 -----LVHDKQVEEFKGDLGDYQKWLNEQNAQPTITKAQTAPQQLAP--------------

AA01616 -QQTEVLKQVSFAMQQGELVAIVGSSG--SGKSTLLHTLGG--LDQPS---GGIK------

AA01820 ----AALQNINLTVYPNSIITIVGPNG--GGKSTLLKVLLK--LQQPT---SG--------

AA01961 -KDEPALDNISFKIPHGKTVALVGRSG--SGKSTIANLVTR--FYDIN---QGGAS-----

AA02080 -NRVHVLKDISLSIERGDFVAIMGQSG--SGKSTLMNIIGC--LDTAT---GG--------

AA02140a ----TALYDVSLRIPRGATVGLIGPDG--VGKSTLLSLIAG--VKIIQ---TGSVQVFDLN

AA02140b ---FVSVDNVSFTIPKGEIFGFLGSNG--CGKSTTMKMLTG--LLDPT---EG--------

A02145 ---IPLLNGIDLELKAGELLTILGANG--TGKSTLLNCIAG--LLKP---KCGNK------

AA02146 --------WLMFRSIRR--------------RRINTRCWIT--WEPP--------------

AA02225 -LTGEGFKNVTFDIYPGEILGLAGVVG--AGRTELAETLYG--SRKQK---CG--------

AA02226 ---VEVLKAIDFSLYAGEVHALLGGNG--AGKSTLMKIIAG---IQP--------------

AA02320 ----QVVSDVSLTVNSGEIVGLLGPNG--AGKTTTFYMVVG--LVNHD---QG--------

AA02331 ---KPIIKDISLIIPAGKSVAIKAPSG--FGKTTLLKLMSG--LLKST---SGLGNN----

AA02440 --QVTALEDINIQIAEGEFVAIMGASG--SGKTTLMNILTG--LDTAS---EG--------

AA02484a ---RHILKNISLSFFPGAKIGVLGLNG--AGKSTLLRIMAG--IDKEI---EG--------

AA02484b ----TLIDDLSFSIPKGAIVGIIGANG--AGKSTLFRMLSG--KEKPD---SG--------

AA02573a ---APLLDHADLHIEPNERVCLVGRNG--AGKSTLLKIIAGDVVMDDG---TK--------

AA02573b ----QLLKDFSTTILRGDKIALVGPNG--CGKTTFIKLLLG--EIQPT---SG--------

AA02642 ------LNDVSFKVKKGESWGLIGTNG--SGKSTLLKLICG--ILKP---YKGDV------

Walker A

AA00061 ---------------AALSAGQQKRIALARLWLSEASLW-ILDEPFNAIDKKGVAVLTALFERHAQHN-GI----VILTSHQEVPSA---

AA00207a -------------LCATLSIGEQQMVEIAKALSFESKVI-VMDEPTDALTNTETEALFKVTRELKAE--NR----GIVYISHRIKEIFQ

AA00207b -------------PIGLLSGGNQQKVSIAKGLMTRPQVL-ILDEPTRGVDVGVKKEIYQLINQFKGE--GM----SIILVSSEMPEVLG

AA00415 --------------PSNLSGGQKQRVAIARALASNPKVL-LCDEATSALDPATTQSILKLLKEINRTL-GI----TILLITHEMDVVKR

AA00700 --------------VDQISGGQQQRVALARALVLKPKVL-LFDEPLSNLDANLRRAMREKIRELQQSL-GI----TSLYVTHDQTEAFA

AA00751a -------------KVAKLSVSQMQMIEIAKAFSYNAKIV-IMDEPASSLSEKEVEHLFKIIQKLKDR--GC----GIIYISHKMDEIFK

AA00751b -----------VTTIGSLSGGNQQKVIIGRWLLTQPEIL-MLDEPTRGIDIGAKFEIYQLIQELAKK--DK----GIIMISSEMPELLG

AA00799 -------------LVSDLSGGQQQRVFLAMTLAQDAELV-LLDEPTTYLDLNRQAELMGMMRQMQ--QNGK----TVITVLHDLN---

AA00858 --------------PLHLSGGQQQRVAIARALMMKPQVL-LFDEPTAALDPEITAQIVSIIEELQQT--GI----TQVIVTHEVNVAKK

AA00933 ------------DLISDLSIAQQQIVEIAKAVFSEYKII-IFDEPTSSISRKNTEVLFNIIHQLKAK--GV----AMIYISHRLEEFKY

AA00934 ------------QQTKTLSGGNQQKVILARWLESGVDIL-FFDEPTRGIDIGAKSEIYDLMRQFTES--GG----TIVMVSSDLPELIT

AA01051 --------------PHQLSGGQQQRVALARAIAPNPELI-LLDEPFSALDEHLRQKIRHDMLQALRQS-GT----SAIFVTHDRDEALR

AA01456a -------------KVGELGLGQQQLVEIAKALNKQVRLL-ILDEPTASLTEKETAILLNLVKDLRAH--NI----ACIYISHKLNEVKE

AA01456b -----------VLAIGRLSGGNQQKAILAKSLLLKPQIL-ILDEPTRGIDVGAKYEIYKLINQLAQE--GI----AIIVISSELPEVLG

AA01524 --------------PSQLSGGQQQRVGIARALAVQPDII-LLDEPTSALDPELVGEVLQTLKLLAQE--GW----TMIIVTHELQFARD

AA01645 --------------IEQLSGGQQQRVALARALVIAPQIL-LFDEPLSNLDTNLRRTLREMIRHLQQQL-NI----TTLYVTHDQSEAFA

AA01656 --------------PKALSGGQRQRVAIGRTLVSQPEVF-LLDEPLSNLDAALRVQMRVEISKLHKKL-NR----TMIYVTHDQVEAMT

AA01684 --------------PHQLSGGEQQRAAFARVLINPPNLL-LLDEPFSSLDWQTRVHIWQMLNALRQEY-QM----TTLLVTHELKEAEY

AA01685 -----------ATAAVLAAGGHIHRQGLSETLLVFTNHRNLLDNPTDYQAIVSQLRLEAPENKITLEADNFSQFEQMLAAEPDIIQLDK

AA01779 --------------PITLSGGEKQRVAIGRALLTDPEIL-LMDEPLSALDLPRKRELLNYLERLSKEI-NI----PILYVTHSIDELLR

AA01824 --------------LSELSGGQRQRALIAMTFCQKTDHV-LLDEPLNNLDIFHARELMRLLRQLTN-ELAL----TTVMVVHDIN----

AA01867 -----------SRLPNSLSGGQKQRVALARCLLRDKPIL-LLDEPFSALDPELRMEMLNLIDELCRSK-HL----TLLLVTHQPSELAG

AA01947 --------------PSELSGGQQQRVALARAMVTRPDVI-LFDEPLSNLDAKLRESVRFEIKQLSKQY-HL----TSIYVTHDQAEALT

AA02152 --------------YHQLSGGEKQLVLIARAIAQQATLL-IMDEPTASLDFGNQIRVLEKIKHLQTQN--I----ALLITTHNPQQAMY

AA02324 ---------------SELSGGMARRAALARAIALDPDLI-MFDEPFTGQDPISMGVIISLIKRLNEAL-NL----TSIVVSHDVQEVLS

AA02353 --------------PRELSGGEQQRIGILRAIAANPHLL-LMDEPFSALDPLVRAALQDQISLIHKKF-GT----TIVFVTHDMQEALK

AA02718 --------------PTQLSGGQQQRIAIARAVVNKPKVL-LLDESLSALDYKLRKQMQYELKVLQRQL-GI----TFIFVTHDQEEAIT

AA02786a -------------KMSDVSVAKAQLVAIATAVSNDAKVI-IMDEPTTALTENEVEQLYRIIETVKER--GI----AIIFISHKLDEVFR

AA02786b -----------AVITNNLSGGNQQKVLLARWLLLEPDIL-ILDEPTKGIDVGAKAELYKLMVELSKQ--GK----TIIMITSDMLELLS

AA02898 -----------LMYPHEFSGGMRQRVMIAMALLCRPKLL-IADEPTTALDVTVQAQIMTLLNELKHEF-NT----AIIMITHDLGVVAG

AA02899 -----------LRYPHEFSGGQCQRIGIARALIIEPKMI-ICDEPVSALDVSIQAQVVNLLKSLQKEM-DL----SLIFIAHDLAVVKH

AA00591 --------------SRILSLGEQQRLAFARLLLHKPQVA-FLDEATASLDEGLENAMYRLIRHTLPN---T----TIISVGHRSALVPL

AA01393 -----------------LSGGQRQRIAIARVMLKDAPIL-LLDEATSALDSEVEAAIQESLDKMMEN---K----TVIAIAHRLSTIAA

AA01422 -------------LPAHLSGGEQQRIDIARAVVHKPQLL-LADEPTGNLDGALSLEIFNLFEEFNR--LGM----TVLIATHDIGIVQQ

AA01509 -----------------LSGGQIQRLALARALLHNADVY-IFDEATSNIDVESEEIILQFIQQLKHS---K----TIVMISHRLANAMN

AA01510 -----------------LSDGEKQRIGIARAFLHNAPII-LLDEPTSNLDSLNEAMILQSLLNVKAE---K----LIILVSHRASTMAI

AA01555a --------------VKAFSGGWRMRLNLAQALICRSDLL-LLDEPTNHLDLDAVIWLERWLKQYPG---------TLILISHDRD----

AA01555b --------------VASFSGGEKARLVLALIVWQRPNLL-LLDEPTNHLDFRYASGVNGSLGGLSG----------LFGVGVARSP---

AA01556 --------------LRKQATQLENQMEKLGAQLQHIET--ALADP-NVYDAEMKAKLTALLNDQVQT--------KKQLEVEAAWLVLQ

AA01616 -----------GQAPSALSGGERQRVAIARALVNNPALV-LADEPTGNLDHKTTESIFELIQQLNQEK-HI----AFLLVTHDLSLAE-

AA01820 --------------MQKLSGGEMQRVLLARAILNKPSLL-VLDEPTQGVDIAGQAELYQLIHQTRE-NLNC----AILMVSHDLHIV--

AA01961 -----------------LSGGQRQRLAIARALLRNSPVL-ILDEATSALDTESERAIQAALEEIQKD---R----TVLVIAHRLSTIEK

AA02080 --------------PNQLSGGQQQRVSIARALMNGGEII-LADEPTGALDSHSGENVMEILRQLHEEG-H-----TIIMVTHDKHIAA-

AA02140a GLGKNLYLTLSIRIAGKLSGGMKQKLSLCCALVHSPDLL-ILDEPTTGVDPLSRRQFWQLVEDLRREENGM----TVIVATAYI-----

AA02140b --------------PSALPLGIRQRLQLAAACLHKPEVL-ILDEPTSGVDPAARDMFWEYLIKLSRED-KI----TIFVTTHFMNEAAC

A02145 -------------EIKQLSAKQGTGAGTTEHSPFCRQNL-YANERRRKAAGEFSQ----------NS--GA---------TAATDFV--

AA02146 --------------YMQMSGGEKQLVNLAKILVQQPQLI-LFDEPTSALDYGNVFKTLSLIKGLSHQQ--F----SIIMTTHNPDHPML

AA02225 -------------AVRTLSGGNQQKVLIAKCLEADPALL-IVDEPTRGVDVGARADIYQLIKNISKQ--NV----AVLFISSDLEEIEH

AA02226 ------------------------------------------------------Q----------DS--G-------------------

AA02320 ---------------QSLSGGERRRVEIARALAANPKFI-LLDEPFAGVDPISVIDIKKIIKDLRDR--GL----GVLITDHNVRETLD

AA02331 -----------------LSGGQRQRLFIARALYKRPYIL-FMDEATSYLDEKNEKAIN--ISISQLN---I----TRVIVAHRQSTIDS

AA02440 --------------PSQLSGGEQQRVCIARALVNQPPVI-FADEPTGNLDEKNEHLVLDLLTELNRQG-R-----TIVMVTHNPDLGK-

AA02484a --------------IEHLSGGERRRVALCRLLLEKPDML-LLDEPTNHLDAESVAWLERFLHDYEG---------TVVAITHDRY----

AA02484b --------------VGELSGGERGRLHLAKLLQAGGNML-LLDEPTNDLDVETLRALENAILEFPG---------CAMVISHDRW----

AA02573a --------------LADLSGGWLRKAALARALVCNPDVL-LLDEPTNHLDVDAIEWLENFLMEFSG---------SIVFISHDRS----

AA02573b --------------VKALSGGERNRLLLAKLLLKPNNLL-ILDEPTNDLDVETLELLEEILTDYQG---------TLLIVSHDRQ----

AA02642 -------------PIKNFSSGMSARLGFSIATIVKPEIL-IIDEVLAVGDAAFQEKCKKRMTEMLES--GT----TLLFVSHSVDQVKE

Signature Walker B Downstream Region