Plasma membrane organization of the 4 protein domains of the main types of ABC transporters encountered in Streptococcus mutans and gene organization.


Domain Type

NBD protein

MSD protein

SBP Protein

Function

NBD1

NBD2

MSD1

MSD2

SBP1

SBP2

1

SMu0235

SMu0234

SMu0233

SMu0232

SMu0231

oligopeptide

1

SMu1037

SMu1036

SMu1038

SMu1039

SMu1040

phosphate

1

SMu1518

SMu1517

SMu1520

SMu1519

SMu1521

branched chain amino acids

2

SMu1428

SMu1426

SMu1427

SMu1425

maltose

2

SMu0805

SMu0802

SMu0803

SMu0801

melibiose/raffinose

2

SMu0884

SMu0886

SMu0885

SMu0887

spermidine/putresceine

2

SMu0849

SMu0848

SMu0847

SMu0846

glutamine/truncation

2

Smu1380

Smu1382

Smu1383

Smu1381

amino acid

2

SMu0907

SMu0905

SMu0906

SMu0908

iron (III)

2

SMu1920

SMu1921

SMu1923

SMu1922

glycine betaine/carnitine/choline

2

SMu1050

SMu1051

SMu1052

SMu1051

???

2

SMu1649

SMu1648

SMu1647

???

3

SMu1762

SMu1761

SMu1765

SMu1764

???

3

SMu0218

SMu0219

SMu0219

glutamine?

3

SMu0216

SMu0215

sodium ion?

3

SMu1003

SMu1002

choline????

3

SMu1079

SMu1080

SMu1078

amino acid

3

Smu0517

Smu0516

Smu0516

amino acid

3

SMu0731

SMu0732

SMu0732

amino acid

3

SMu1210

SMu1209

FtsEX cell division

3

SMu0164

SMu0165

SMu0166

manganese ion

3

SMu0418

SMu0417

SMu0416

amino acid?

3

SMu1811

SMu1810

SMu1189

zinc ion

3

SMu0594

SMu0595

SMu0593

anion

3

SMu1316

SMu1317

SMu1317

???

3

SMu0976

SMu0975

SMu0975

???

3

Smu1093

Smu1094

???

3

SMu0786

SMu0787

???

3

SMu1068

SMu1067

???

3

SMu0596

SMu0598

???

3

SMu1410

SMu1409

efflux

3

SMu0971

SMu0970

glycine betaine

3

SMu1246

SMu1245

???

3

SMu1231

SMu1230

???

3

SMu0944

SMu0945

???

3

SMu1751

SMu1752

???

3

SMu0335

SMu0336

???

3

SMu1545

SMu1544

???

3

SMu0666

SMu0667

???

3

SMu0752

SMu0751

???

3

SMu1202

SMu1203

???

3

SMu0374

SMu0375

???

3

SMu1001

SMu1000

???

3

SMu0916

SMu0917

???

3

Smu0390

SMu0391

???

4

SMu1023

SMu1023

SMu1022

SMu1021

SMu1024

galactose

4

SMu1757

SMu1757

SMu1756

SMu1758

SMu1756

???

5

Smu0258

Smu0258

SMu0259

peptide toxin efflux

5

SMu1724

SMu1724

SMu1726

peptide toxin efflux

5

SMu1288

SMu1288

???

5

SMu1710

SMu1710

???

6

SMu1065

SMu1064

SMu1065

SMu1064

drug efflux

6

SMu0476

SMu0475

SMu0476

SMu0475

???

6

SMu0986

SMu0987

SMu0986

SMu0987

???

6

SMu0825

SMu0824

SMu0825

SMu0824

drug efflux

6

SMu0836

SMu0837

SMu0836

SMu0837

???

7

SMu1950

SMu1949

SMu1948

???

8

SMu0950

SMu0951

SMu0951

???

9

SMu0823

SMu0823

SMu0826

???

11

Smu1959

Smu1959

Smu1960

Smu1960

???


Plasma membrane organization of the four protein domains of the main types of ABC transporters encountered in Streptococcus mutans and organization of the chromosomal region containing the genes encoding one particular member. The membrane-spanning domains (MSDs) and the two nucleotide-binding domains (NBDs) are depicted by ovals and triangles, respectively. When fused, domains are linked together using a large connecting area.