Basic Search | Intermediate Search | Advanced SQL Search | Gene Image Map |  Home

Ureaplasma urealyticum Search Results

Record: 1 of 1  
MiniMap IGR175 IGR167 IGR172 IGR173 IGR176 IGR168 IGR170 IGR169 IGR177 IGR178 IGR174 IGR171 UU208 rpL21, - UU212 rpL27, - UU210 UU211 UU209 plsX, - UU206 UU207 rpL28, - UU209.1 ptc1, - UU215 UU217 UU214 pkn, - UU216 amt, - UU218 UU208 rpL21, - UU212 rpL27, - UU210 UU211 UU209 plsX, - UU206 UU207 rpL28, - UU209.1 ptc1, - UU215 UU217 UU214 pkn, - UU216 amt, - UU218 Type: tandem, Name:  - 135 Type: tandem, Name:  - 132 Type: tandem, Name:  - 137 Type: tandem, Name:  - 133 Type: tandem, Name:  - 134 Type: tandem, Name:  - 136 Type: tandem, Name:  - 427 UU208 UU211 UU209 plsX, - UU206 UU207 rpL21, - UU212 rpL27, - UU210 rpL28, - UU209.1 ptc1, - UU215 UU217 UU214 pkn, - UU216 amt, - UU218 gmk, - UU213 gmk, - UU213
* Calculated from Protein Sequence

Gene ID: UU213

DNA Molecule Name:
1  

Genbank ID:


Gene Name:
gmk  

Definition:
guanylate kinase

Gene Start:
256118

Gene Stop:
256693

Gene Length:
576

Molecular Weight*:
21990

pI*:
9.70

Net Charge*:
3.73

EC:
2.7.4.8  

Functional Class:
purines, pyrimidines, nucleosides, and nucleotides; nucleotide and nucleoside interconversions  

Pathway: pathway table
Purine metabolism

Comment:
This protein is essential for recycling GMP and, indirectly, cGMP. See Prosite PDOC00670.

Blast Summary:  PSI-Blast Search
Numerous hits in gapped BLAST to guanylate kinases, e.g. residues 2-187 are 50% similar to BSY13937 of B.subtilis.
UU213 is similar to MG107 of M.genitalium and CT030 of C.trachomatis, both of which are attributed to guanylate kinase.
No similarity to T.pallidum.

COGS Summary:  COGS Search
The phylogenetic pattern of COG0194 is Ehgpc-yu.
Cog name: Guanylate kinase.
Functional class: F.
BeTs to e-g-c-yu.
Number of proteins in this genome belonging to this COG is 1



Blocks Summary:  Blocks Search
Residues 8-20, 36-56, and 64-111 represent blocks BL00856A-C (guanylate kinase proteins).
Probably meaningless similarities are seen to blocks PR00364A (disease resistance proteins),
PD1095B,F,G (glycogen starch biosynthesis sy.) Residues 4-21 represent block Pr00988A (uridine kinase signature).

ProDom Summary:  Protein Domain Search
Residues 47-106 and 122-187 are 58% and 43% similar to guanylate kinase domains of O34328_BACSU.


Paralogs:  Local Blast Search
No paralogs in U.u.

Pfam Summary:  Pfam Search
Residues 40 to 146 (E-value = 5e-34) place UU213 in the Guanylate_kin family which is described as Guanylate kinase (PF00625)

Structural Feature(s):
Feature Type  Start  Stop
coil-coil  
129  
157

PDB Hit:
gi|494043|pdb|1GKY| Guanylate Kinase (E.C.2.7.4.8) Complex With Guanosine Monophosphate

Gene Protein Sequence:
MKRGKLIVFSGPSGVGKHTILSKIINRKDLNLAYSISMTTRKKREGEVNG
VDYYFVNDEEFKKAILNNELIEWAEFVGNKYGTPRTIVEKLRDEGKNVIL
EIEVVGALKVLDLYKNDDLISIFLLPPSIDELKKRLLKRNTETLETIKKR
IQKATHEITIKDYYQYNIINDNPDHAANQLAEIILNEIKQS$

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAACGCGGAAAATTAATTGTTTTTAGTGGACCTAGTGGTGTAGGAAA
ACATACAATTCTATCTAAAATCATAAATCGTAAAGATTTAAATTTAGCAT
ATAGTATTTCAATGACAACCCGAAAAAAACGTGAAGGTGAAGTTAATGGT
GTTGATTATTATTTTGTTAATGATGAAGAATTTAAAAAGGCCATACTAAA
TAATGAATTAATTGAGTGAGCTGAGTTTGTTGGAAATAAATATGGAACAC
CACGAACTATTGTTGAAAAATTAAGAGATGAAGGAAAAAATGTTATTTTA
GAAATTGAGGTTGTAGGTGCACTTAAAGTTTTAGATTTATATAAAAATGA
TGATTTAATTTCTATTTTTTTATTACCACCAAGTATTGATGAATTAAAAA
AACGCTTATTAAAAAGGAATACAGAAACATTAGAAACAATTAAAAAAAGA
ATTCAAAAAGCTACTCATGAAATAACAATAAAAGATTATTATCAATATAA
TATTATTAATGATAATCCAGATCATGCAGCAAACCAGTTGGCGGAGATTA
TTCTAAATGAAATTAAACAATCATAA


Los Alamos National Laboratory     
Operated by the University of California for the National Nuclear Security Administration,
of the US Department of Energy.     Copyright © 2001 UC | Disclaimer/Privacy