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Treponema pallidum Search Results

Record: 1 of 1  
MiniMap IGR747 IGR745 IGR741 IGR743 IGR744 IGR742 IGR746 ndk, - TP1010 pth, - TP1011 thy1, - TP1007 sigA,rpoD, - TP1012 gpsA, - TP1009 tpn39b,bmp, - TP1016 TP1014 nrdA, - TP1008 groES, - TP1013 ndk, - TP1010 pth, - TP1011 thy1, - TP1007 sigA,rpoD, - TP1012 gpsA, - TP1009 tpn39b,bmp, - TP1016 TP1014 nrdA, - TP1008 groES, - TP1013 ndk, - TP1010 pth, - TP1011 thy1, - TP1007 sigA,rpoD, - TP1012 gpsA, - TP1009 TP1014 nrdA, - TP1008 nusB, - TP1015 tpn39b,bmp, - TP1016 nusB, - TP1015 groES, - TP1013
* Calculated from Protein Sequence

Gene ID: TP1010

DNA Molecule Name:
1  

Genbank ID:
3323338

Gene Name:
ndk  

Definition:
nucleoside-diphosphate kinase

Gene Start:
1102271

Gene Stop:
1101825

Gene Length:
447

Molecular Weight*:
16641

pI*:
6.93

Net Charge*:
-0.14

EC:
2.7.4.6  

Functional Class:
Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions  

Pathway: pathway table
Nucleotide metabolism; Purine Metabolism
Nucleotide metabolism; Pyrimidine Metabolism

Comment:
This protein plays a major role in the synthesis of nucleoside
triphosphates other than ATP.

Reaction:
ATP + NUCLEOSIDE DIPHOSPHATE = ADP + NUCLEOSIDE TRIPHOSPHATE.

Blast Summary:  PSI-Blast Search
Gapped BLAST revealed several significant hits to nucleoside-diphosphate
kinases. For example residues 4-142 are 48% similar to NDK_BACSU,
nucleoside-diphosphate kinase of Bacillus subtilis,(Z99115).

COGS Summary:  COGS Search
BeTs to 15 clades of COG0105
COG name: Nucleoside diphosphate kinase
Functional Class:  F
The phylogenetic pattern of COG0105 is amtkyq-cebrhuj--olinx
Number of proteins in this genome belonging to this COG is 1

Blocks Summary:  Blocks Search
Residues 4-38, 48-91, and 92-133 represent significant (100%) hits to
blocks BL00469A,B,C, Nucleoside diphosphate kinases proteins.

ProDom Summary:  Protein Domain Search
Residues 4-133 are 51% similar to nucleoside-diphosphate kinase of
NDK_BACSU.

Paralogs:  Local Blast Search
There is no evidence of paralogs in T. pallidum.

Pfam Summary:  Pfam Search
Residues 4 to 141 (E-value = 9.9e-63) place TP1010 in the NDK family which is described as Nucleoside diphosphate kinase (PF00334)

PDB Hit:
gi|1943528|pdb|1LEO| P100s Nucleoside Diphosphate Kinase Enzyme, Transferase, Kinase Mol_id: 1; Molecule: Nucleoside Diphosphate Kinase; Chain: Null; Synonym: Ndp Kinase; Ec: 2.7.4.6; Engineered: Yes; Mutation: P100s

Gene Protein Sequence:
MAFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELH
YAEHREKPFYPSLIAYITSAPVVALAFKGENAISLVRTLCGSTRVEHAQP
GTIRGDFALRTTTNIVHASDSPESAARELALYFSAQDFVEWRDGNYDFF

Gene Nucleotide Sequence:  Sequence Viewer
ATGGCATTTGAAACAACTTTCGTCATGCTTAAGCCGGGTGTTCTTCAACG
TAGACTGGTAGGGGAGGTTTTGAGTCGCTTCGAGCGCAAAGGGCTCGTGC
TGACTGCGCTCAGGCTGTTGTGCGTCGATACAGCTACTGCGGAGTTGCAT
TACGCGGAGCATCGCGAGAAGCCTTTTTATCCTTCGCTTATCGCTTATAT
TACGAGCGCACCGGTGGTTGCACTCGCATTCAAGGGGGAGAATGCTATCA
GTCTTGTGCGCACGCTTTGTGGCTCTACGCGTGTGGAGCACGCTCAACCG
GGAACGATTCGTGGTGATTTTGCGCTACGCACCACTACTAATATTGTCCA
TGCTTCTGATTCTCCCGAGAGCGCTGCACGAGAACTAGCGCTCTACTTTT
CTGCGCAAGATTTTGTTGAATGGCGTGACGGGAATTACGATTTTTTC


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