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Treponema pallidum Search Results

Record: 1 of 1  
MiniMap IGR591 IGR592 IGR589 IGR594 IGR595 IGR593 IGR588 IGR590 IGR587 IGR596 TP0818 rbo,dfx, - TP0823 TP0816 TP0820 tpn32, - TP0821 TP0822 TP0819 TP0813 eno, - TP0817 trxB, - TP0814 TP0815 TP0812 TP0818 rbo,dfx, - TP0823 TP0816 TP0820 tpn32, - TP0821 TP0822 TP0819 TP0813 eno, - TP0817 trxB, - TP0814 TP0815 TP0812 Type: tandem, Name:  - 185 rbo,dfx, - TP0823 TP0816 TP0820 tpn32, - TP0821 TP0822 TP0819 TP0813 eno, - TP0817 TP0818 trxB, - TP0814 TP0815 TP0812
* Calculated from Protein Sequence

Gene ID: TP0817

DNA Molecule Name:
1  

Genbank ID:


Gene Name:
eno  

Definition:
enolase

Gene Start:
886888

Gene Stop:
885593

Gene Length:
1296

Molecular Weight*:
0

pI*:
4.80

Net Charge*:
-14.09

EC:
4.2.1.11  

Functional Class:
Energy metabolism; Glycolysis  

Pathway: pathway table
Carbohydrate metabolism; Glycolysis / Gluconeogenesis

Primary Evidence:
Stamm LV, Young NR. 1997. Nucleotide sequence of the Treponema pallidum eno gene. DNA Seq;7(5):261-5. Medline: 97399390.



Secondary Evidence:
Kaga N, Umitsuki G, Nagai K, Wachi M.
RNase G-dependent degradation of the eno mRNA encoding a glycolysis enzyme enolase in Escherichia coli.
Biosci Biotechnol Biochem. 2002 Oct;66(10):2216-20.
PMID: 12450135

Bergmann S, Rohde M, Chhatwal GS, Hammerschmidt S.
alpha-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface.
Mol Microbiol. 2001 Jun;40(6):1273-87.
PMID: 11442827

Rompf A, Schmid R, Jahn D.
Changes in protein synthesis as a consequence of heme depletion in Escherichia coli.
Curr Microbiol. 1998 Oct;37(4):226-30.
PMID: 9732527

Mahony TJ, Miller DJ.
Linkage of genes encoding enolase (eno) and CTP synthase (pyrG) in the beta-subdivision proteobacterium Nitrosomonas europaea.
FEMS Microbiol Lett. 1998 Aug;165(1):153-7.
PMID: 9711852

Comment:
Reaction:
2-PHOSPHO-D-GLYCERATE = PHOSPHOENOLPYRUVATE + H(2)O.

Blast Summary:  PSI-Blast Search
Gapped BLAST revealed this protein is identical to enolase of T. pallidum
(U61534). In addition gapped BLAST revealed several significant hits
to enolase proteins. For example residues 1-427 are 59% similar to
ENO_BACSU, enolase of Bacillus subtilis,(Z99121).

COGS Summary:  COGS Search
BeTs to 16 clades of COG0148
COG name: Enolase
Functional Class:? G
The phylogenetic pattern of COG0148 is aMtKYqvcebrhujgpolin-
Number of proteins in this genome belonging to this COG is 1

Blocks Summary:  Blocks Search
Residues 34-72, 90-139, 149-198, 141-187, 216-260, 214-258, 283-300,
311-361, 378-416, and 308-346 represent significant (100%) hits to blocks
BL00164A,B,C,D,E,F,G, Enolase proteins. Residues 110-136 and 249-303
represent significant (96%) hits to blocks BL00908A,B, Mandelate racemase/
muconate lactonizing enzyme family signature.

ProDom Summary:  Protein Domain Search
Residues 7-415 are 61% similar to enolase as represented by ENO_BACSU.

Paralogs:  Local Blast Search
There is no evidence of paralogs in T. pallidum.

Pfam Summary:  Pfam Search
Residues 3 to 134 (E-value = 3.2e-65) place TP0817 in the Enolase_N family which is described as Enolase, N-terminal domain (PF03952)
Residues 139 to 430 (E-value = 4.1e-162) place TP0817 in the Enolase_C family which is described as Enolase, C-terminal TIM barrel domain (PF00113)

PDB Hit:
None

Gene Protein Sequence:
MSDIACIEAREIIDSRGNPTVEVDVSLSDGSFGRACVPSGASTGEFEALE
MRDGDKERYNGKGVLKAVGTVNTLIADTLEGMDALNQGEIDHAMRNLDGT
DNKSKLGANAMLGVSMACARAAADFLGVPLYRYLGGVHTFRMPVPMANII
NGGKHSDNKIDFQEFMVMPIGAASMREAVRMTAEVFHALKGLLAADGKAT
SVGDEGGFAPDLDNEQALEYIMKAIAKAGLAPRKDVCIALDCASSELFDE
GDRRGYKFWKSNPGKLFTAQEMIDLYKKWIATYPIVSIEDPLDQNDWAGY
VQLTKELGDKVQIVGDDFFVTNTGRLARGIKEGSCNSILIKLNQIGTVTE
TVDAVRMAQNAGYAAVISHRSGETEDAFIADLAVALETGQIKTGSMSRSD
RVAKYNQLMRIEEELGAQARYYGAKTFERFGC

Gene Nucleotide Sequence:  Sequence Viewer
GTGAGTGACATTGCATGCATTGAAGCGCGCGAGATCATCGATTCTCGGGG
AAACCCCACTGTCGAAGTGGATGTCTCGCTCAGTGACGGTAGCTTTGGCC
GTGCGTGTGTTCCTTCAGGGGCGTCTACCGGAGAGTTCGAGGCGCTCGAA
ATGCGTGATGGAGACAAGGAGCGCTATAACGGTAAGGGTGTTCTCAAGGC
CGTTGGAACTGTCAACACGCTCATTGCTGATACGCTCGAAGGTATGGATG
CGCTCAACCAGGGTGAGATAGATCACGCGATGCGGAATCTGGACGGCACT
GACAATAAGTCAAAGCTTGGTGCGAATGCTATGCTTGGCGTCTCCATGGC
TTGTGCGCGTGCTGCTGCAGACTTTCTGGGTGTTCCTCTCTACCGTTACC
TCGGTGGTGTGCACACTTTTCGCATGCCGGTCCCTATGGCCAACATTATC
AATGGGGGGAAGCATTCTGATAATAAAATTGACTTTCAAGAGTTTATGGT
TATGCCCATCGGCGCTGCGTCCATGCGCGAAGCGGTGCGCATGACCGCAG
AGGTGTTCCACGCGTTAAAGGGCCTGCTTGCCGCCGACGGCAAAGCTACG
TCAGTTGGTGATGAAGGTGGTTTTGCGCCTGATTTGGATAACGAGCAAGC
CCTTGAGTACATTATGAAAGCGATCGCAAAAGCCGGCCTTGCGCCGCGGA
AGGATGTGTGTATTGCGCTTGACTGTGCGTCTTCTGAGTTATTCGATGAA
GGAGATCGGAGAGGGTACAAGTTTTGGAAGTCGAATCCGGGGAAGCTGTT
CACAGCACAGGAAATGATTGATCTGTACAAGAAGTGGATTGCTACGTATC
CGATTGTGTCTATCGAGGATCCGCTTGACCAAAACGACTGGGCAGGTTAC
GTGCAGCTCACGAAAGAGTTGGGAGACAAAGTCCAAATTGTGGGAGATGA
TTTTTTTGTAACCAACACTGGGCGTCTGGCCCGAGGTATCAAAGAAGGAT
CGTGCAATTCGATTCTGATAAAACTTAATCAGATTGGCACGGTCACAGAA
ACTGTCGACGCGGTGCGTATGGCTCAGAACGCAGGCTACGCGGCGGTGAT
TTCACATCGCTCGGGTGAGACAGAGGATGCGTTTATCGCAGACTTAGCAG
TGGCACTTGAGACAGGTCAAATCAAAACCGGCTCGATGAGTCGCAGTGAC
CGGGTGGCGAAGTATAACCAGTTGATGCGCATTGAGGAAGAGTTGGGTGC
ACAGGCGCGCTACTACGGGGCAAAGACCTTTGAGCGGTTTGGTTGT


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