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Treponema pallidum Search Results

Record: 1 of 1  
MiniMap IGR268 IGR261 IGR265 IGR266 IGR264 IGR260 IGR263 IGR267 IGR259 IGR262 TP0355 rnh, - TP0353 TP0359 plsC, - TP0361 TP0348 TP0358 TP0360 TP0352 TP0356 tmk, - TP0354 birA, - TP0357 proB, - TP0351 gpr,proA, - TP0350 TP0355 rnh, - TP0353 TP0359 plsC, - TP0361 TP0348 TP0358 TP0360 TP0352 TP0356 tmk, - TP0354 birA, - TP0357 proB, - TP0351 gpr,proA, - TP0350 Type: tandem, Name:  - 247 Type: tandem, Name:  - 83 Type: tandem, Name:  - 84 Type: tandem, Name:  - 85 TP0355 rnh, - TP0353 TP0359 plsC, - TP0361 TP0348 TP0358 slyD, - TP0349 slyD, - TP0349 TP0360 TP0352 TP0356 tmk, - TP0354 birA, - TP0357 proB, - TP0351 gpr,proA, - TP0350
* Calculated from Protein Sequence

Gene ID: TP0354

DNA Molecule Name:
1  

Genbank ID:
3322633

Gene Name:
tmk  

Definition:
thymidylate kinase

Gene Start:
377970

Gene Stop:
378593

Gene Length:
624

Molecular Weight*:
23933

pI*:
6.72

Net Charge*:
-1.25

EC:
2.7.4.9  

Functional Class:
Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions  

Pathway: pathway table
Nucleotide metabolism; Pyrimidine Metabolism

Secondary Evidence:
Reynes,J.P., Tiraby,M., Baron,M., Drocourt,D. and Tiraby,G. 1996. Escherichia coli thymidylate kinase: molecular cloning, nucleotide sequence, and genetic organization of the corresponding tmk locus. J. Bacteriol. 178(10): 2804-2812.
Medline: 96213019

Comment:
This enzyme is involved in the synthesis of dTTP from dTMP.

Reaction:
ATP + THYMIDINE 5'-MONOPHOSPHATE = ADP + THYMIDINE 5'-DIPHOSPHATE.

Blast Summary:  PSI-Blast Search
Gapped BLAST revealed several significant hits to thymidylate kinases. For example residues 1-171 are 38% similar to thymidylate kinase of Borrelia burgdorferi,(AE001178).

COGS Summary:  COGS Search
BeTs to 17 clades of COG0125
COG name: Thymidylate kinase
Functional Class:  F
The phylogenetic pattern of COG0125 is AmTkyqvceBrhujgpolinx
Number of proteins in this genome belonging to this COG is 1

Blocks Summary:  Blocks Search
None.

ProDom Summary:  Protein Domain Search
Residues 7-145 are 37% similar to thymidylate kinase of KTHY_METJA.

Paralogs:  Local Blast Search
There is no evidence of paralogs in T. pallidum.

Pfam Summary:  Pfam Search
Residues 10 to 197 (E-value = 5.5e-81) place TP0354 in the Thymidylate_kin family which is described as Thymidylate kinase (PF02223)

PDB Hit:
none

Gene Protein Sequence:
MNILHNFVVFEGIDGTGTSTQLRALERHFQARKDMVFTQEPTGGEIGTLI
RDVLQKRVIMSSKALGLLFAADRHEHLEGAGGINDCLAEGKIVLCDRYVF
SSLVYQGMAVSGSFAYELNKEFPLPEVVFYFDAPIEVCVERITARGLQTE
LYEYTSFQEKARKGYETIFRKCRHLYPAMKVIEIDAREEIEVVHERILHH
LREYRRLK

Gene Nucleotide Sequence:  Sequence Viewer
ATGAATATTCTGCATAACTTTGTTGTATTCGAAGGTATTGATGGCACAGG
CACGAGTACACAGTTGCGTGCGCTCGAACGCCATTTTCAGGCCCGTAAGG
ACATGGTCTTTACTCAAGAGCCTACCGGAGGGGAGATTGGCACTCTCATT
CGGGATGTGCTGCAAAAGCGTGTGATCATGAGCTCTAAGGCATTGGGATT
GCTCTTTGCCGCAGATAGACACGAGCACTTGGAAGGTGCAGGAGGCATTA
ACGATTGTCTTGCAGAAGGAAAGATAGTGCTCTGCGATCGGTATGTTTTT
TCCAGTTTGGTGTACCAAGGCATGGCGGTGTCGGGTAGTTTCGCGTATGA
ATTAAATAAAGAGTTTCCGCTTCCTGAAGTTGTGTTCTATTTTGACGCGC
CTATCGAAGTATGTGTTGAGCGTATCACCGCACGTGGGCTGCAAACGGAA
CTGTATGAGTACACGTCTTTTCAAGAAAAGGCGCGCAAGGGGTATGAAAC
TATATTTCGCAAGTGCCGTCATTTGTACCCTGCAATGAAAGTGATTGAAA
TAGACGCGCGCGAGGAAATTGAAGTTGTGCATGAGCGTATTCTTCACCAT
CTGCGCGAATACAGGCGTCTAAAA


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