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Treponema pallidum Search Results

Record: 1 of 1  
MiniMap IGR261 IGR264 IGR260 IGR258 IGR263 IGR259 IGR262 TP0355 rnh, - TP0353 TP0348 TP0352 TP0356 tmk, - TP0354 birA, - TP0357 TP0347 proB, - TP0351 mraY, - TP0345 gpr,proA, - TP0350 TP0355 rnh, - TP0353 TP0348 TP0352 TP0356 tmk, - TP0354 birA, - TP0357 TP0347 proB, - TP0351 mraY, - TP0345 gpr,proA, - TP0350 Type: tandem, Name:  - 83 Type: tandem, Name:  - 80 Type: tandem, Name:  - 85 Type: tandem, Name:  - 81 Type: tandem, Name:  - 82 Type: tandem, Name:  - 84 Type: tandem, Name:  - 247 TP0355 rnh, - TP0353 TP0348 slyD, - TP0349 slyD, - TP0349 TP0352 TP0356 tmk, - TP0354 birA, - TP0357 TP0347 proB, - TP0351 mraY, - TP0345 gpr,proA, - TP0350 TP0346 TP0346
* Calculated from Protein Sequence

Gene ID: TP0350

DNA Molecule Name:
1  

Genbank ID:


Gene Name:
gpr  proA  

Definition:
gamma-glutamyl phosphate reductase (glutamate-5-semialdehyde dehydrogenase)

Gene Start:
374639

Gene Stop:
375922

Gene Length:
1284

Molecular Weight*:
46596

pI*:
7.92

Net Charge*:
5.26

EC:
1.2.1.41  

Functional Class:
Amino acid biosynthesis; Glutamate family  

Pathway: pathway table
Metabolism of cofactors, vitamins, and other substances; Porphyrin and chlorophyll metabolism

Primary Evidence:
Stamm LV, Barnes NY. 1997. Nucleotide sequences of the proA and proB genes of Treponema pallidum, the syphilis agent. DNA Seq;8(1-2):63-70. Medline: 98182590.

Comment:
This reaction is the second step in the proline biosynthesis pathway.

Reaction:
L-GLUTAMATE 5-SEMIALDEHYDE + ORTHOPHOSPHATE + NADP(+) =
L-GAMMA-GLUTAMYL 5-PHOSPHATE + NADPH.


Blast Summary:  PSI-Blast Search
Gapped BLAST revealed that this protein is identical to PROA_TREPA,
gamma-glutamyl phosphate reductase of Treponema pallidum,(U61535).
In addition it also revealed several significant hits to other
gamma-glutamyl phosphate reductases. For example residues 22-427 are
45% similar to PROA_ECOLI, gamma-glutamyl phosphate reductase of
E. coli, (U70214).

COGS Summary:  COGS Search
BeTs to 8 clades of COG0014
COG name: Gamma-glutamyl phosphate reductase (proline biosynthesis)
Functional Class:  E
The phylogenetic pattern of COG0014 is ----yqvCebrh-----l---
Number of proteins in this genome belonging to this COG is 1

Blocks Summary:  Blocks Search
Residues 26-67, 34-75, 18-59, 101-151, 182-231, 234-263, 340-394,
and 244-298 represent significant hits to blocks (BL01223A,B,C,D,E),
Gamma-glutamyl phosphate reductase proteins.

ProDom Summary:  Protein Domain Search
This protein is identical to glutamate-5-semialdehyde dehydrogenase
of PROA_TREPA.

Paralogs:  Local Blast Search
There is no evidence of paralogs in T. pallidum.

Pfam Summary:  Pfam Search
No significant hits to the Pfam 11.0 database

Structural Feature(s):
Feature Type  Start  Stop
gram positive signal  
1  
21
non-globular  
22  
240

PDB Hit:
None

Gene Protein Sequence:
MVEVYARLRAAVARLAVCSAAEKDGALRAVRDALHAQREDILRANAQDLA
RAREAGLAAPLVARLALSEHLLEDMLRSLTVLSLQRDPIGEIIEGYTLAN
GLEIRKVRVPLGVVAVIYESRPNVTVDAFALAYKSGNAVLLRAGSAASYS
NAPLLRAIHVGLKKAHGVVDAVAVPPVLEEKYGDVDHILRARGFIDAVFP
RGGAALIRRVVEGAHVPVIETGCGVCHLYVDESANIDVALQIAENAKLQK
PAACNSVETLLVHRAVARPFLHRVQEIFATCEETTRKPGGVDFFCDAESF
SLLTERGARKNVFHAQAETWDREYLDYQVSVRVVPNLEEALRHIARHSTK
HSEVIVTRDRARARRFHQEVDAACVYVNASSRFTDGGQFGMGAEIGVSTQ
KLHARGPMGLCALTTSKYLIDGEGQVRP

Gene Nucleotide Sequence:  Sequence Viewer
ATGGTAGAGGTCTACGCGCGGTTGCGCGCTGCTGTTGCTCGGTTGGCGGT
CTGTAGCGCTGCGGAGAAGGACGGTGCCCTGCGCGCTGTGCGCGATGCGC
TACATGCGCAGCGGGAGGATATCCTGCGTGCAAATGCGCAGGATCTTGCG
CGGGCGCGTGAGGCGGGTCTTGCCGCACCGCTTGTCGCCCGGCTCGCGCT
GAGTGAACACCTTCTTGAGGACATGTTGCGGTCTTTGACTGTTCTTTCGC
TTCAGCGGGATCCTATCGGGGAAATTATAGAAGGGTACACTCTTGCGAAT
GGACTGGAAATCCGGAAGGTACGTGTTCCTCTGGGGGTGGTGGCTGTCAT
CTACGAGTCTCGGCCCAACGTGACCGTAGATGCGTTTGCACTTGCGTACA
AAAGCGGCAATGCGGTGCTCCTGCGCGCAGGTTCTGCAGCGAGTTATTCA
AATGCCCCGCTTTTGCGCGCAATTCACGTGGGTTTGAAGAAAGCGCATGG
TGTCGTGGACGCGGTGGCTGTTCCTCCCGTTTTGGAGGAAAAATATGGTG
ATGTGGATCATATCCTCCGCGCGCGCGGCTTTATCGATGCGGTATTTCCT
CGTGGGGGGGCGGCGCTTATCCGGCGCGTCGTGGAAGGCGCCCACGTGCC
AGTTATTGAAACCGGATGCGGCGTGTGCCACCTATACGTAGATGAGAGTG
CGAATATCGATGTGGCGCTGCAGATTGCAGAAAACGCGAAGTTGCAAAAA
CCGGCCGCATGCAATTCAGTCGAAACGCTGTTGGTGCATCGTGCGGTTGC
GCGTCCTTTTTTGCACCGTGTACAGGAGATTTTTGCCACCTGTGAGGAGA
CTACGCGCAAGCCCGGTGGTGTGGATTTTTTTTGTGATGCTGAGTCTTTC
TCCCTTCTCACAGAAAGGGGCGCGAGAAAAAATGTTTTTCATGCACAGGC
AGAGACCTGGGATCGGGAATACCTGGACTATCAGGTATCCGTGCGGGTGG
TGCCAAACCTTGAAGAAGCACTCAGGCACATTGCTCGTCATTCTACGAAA
CACTCAGAGGTTATTGTCACGCGCGATCGTGCCCGTGCGCGTCGTTTTCA
TCAGGAAGTAGATGCTGCCTGTGTATATGTCAATGCTTCAAGTAGGTTTA
CCGATGGAGGGCAGTTTGGCATGGGAGCAGAGATTGGGGTCAGTACGCAA
AAATTGCACGCGCGCGGTCCGATGGGTTTGTGTGCACTGACTACTTCAAA
ATATCTGATTGATGGAGAGGGGCAGGTGCGTCCG


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