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Haemophilus ducreyi Search Results

Record: 1 of 1  
MiniMap tRNA-Ala-1 tRNA-Ile-1 rRNA-16S-1 rRNA-23S-1 IGR7 IGR6 IGR9 IGR8 IGR3 IGR10 IGR5 IGR4 IGR2 IGR11 atpE, - HD0005 HD0003 atpC, - HD0011 atpF, - HD0006 atpH, - HD0007 gidB, - HD0002 atpA, - HD0004 atpG, - HD0009 atpD, - HD0010 atpA, - HD0008 atpE, - HD0005 HD0003 atpC, - HD0011 atpF, - HD0006 atpH, - HD0007 gidB, - HD0002 atpA, - HD0004 atpG, - HD0009 atpD, - HD0010 atpA, - HD0008 atpE, - HD0005 atpC, - HD0011 atpF, - HD0006 atpH, - HD0007 gidB, - HD0002 atpA, - HD0004 atpG, - HD0009 atpD, - HD0010 atpA, - HD0008 HD0003
* Calculated from Protein Sequence

Gene ID: HD0009

DNA Molecule Name:
1  

Genbank ID:
0

Gene Name:
atpG  

Definition:
ATP synthase F1, subunit gamma

Gene Start:
7441

Gene Stop:
8307

Gene Length:
867

Molecular Weight*:
31940

pI*:
9.10

Net Charge*:
4.59

EC:
3.6.1.34  

Functional Class:
Energy metabolism; ATP-proton motive force interconversion  

Pathway: pathway table
Oxidative phosphorylation

Secondary Evidence:
Nielsen,J., Hansen,F.G., Hoppe,J., Friedl,P. and von Meyenburg,K. The nucleotide sequence of the atp genes coding for the F0 subunits a, b, c and the F1 subunit delta of the membrane bound ATP synthase of Escherichia coli.
Mol. Gen. Genet. 184 (1), 33-39 (1981)
Medline: 82147764.

Kanazawa,H., Mabuchi,K., Kayano,T., Noumi,T., Sekiya,T. and Futai,M.
Nucleotide sequence of the genes for F0 components of the proton-translocating ATPase from Escherichia coli: prediction of the primary structure of F0 subunits.
Biochem. Biophys. Res. Commun. 103 (2), 613-620 (1981)
Medline: 82134799.

Cain,B.D. and Simoni,R.D.
Impaired proton conductivity resulting from mutations in the a subunit of F1F0 ATPase in
Escherichia coli.
J. Biol. Chem. 261 (22), 10043-10050 (1986)
Medline: 86278048.

Kumamoto,C.A. and Simoni,R.D.
Genetic evidence for interaction between the a and b subunits of the F0 portion of the Escherichia coli proton translocating ATPase.
J. Biol. Chem. 261 (22), 10037-10042 (1986)
Medline: 86278047.

Cain,B.D. and Simoni,R.D.
Proton translocation by the F1F0ATPase of Escherichia coli. Mutagenic analysis of the a subunit.
J. Biol. Chem. 264 (6), 3292-3300 (1989)
Medline: 89123453.

Yamada,H., Moriyama,Y., Maeda,M. and Futai,M.
Transmembrane topology of Escherichia coli H(+)-ATPase (ATP synthase) subunit a.
FEBS Lett. 390 (1), 34-38 (1996)
Medline: 96314544.

Valiyaveetil,F.I. and Fillingame,R.H.
Transmembrane topography of subunit a in the Escherichia coli F1F0 ATP synthase.
J. Biol. Chem. 273 (26), 16241-16247 (1998)
Medline: 98298136.

Hausrath,A.C., Gruber,G., Matthews,B.W. and Capaldi,R.A. Structural features of the gamma
subunit of the Escherichia coli F(1) ATPase revealed by a 4.4-A resolution map obtained by x-ray crystallography.
Proceedings of the National Academy of Sciences of the United States of America. 96 (24),
13697-13702 (1999)
Medline: 20040613

Comment:
From GenBank (gi:114639): AtpG produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the F0 complex. F-type ATPases have two components, CF(1), the catalytic core, and CF(0), the membrane proton channel. CF(1) has five subunits: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), and EPSILON(1). CF(0) has three main subunits: A, B and C.

See also other chains of the F1 subunit: atpD (delta chain), HD0007; atpB (beta chain), HD0010; atpD (delta chain), HD0008; atpE (epsilon chain), HD0011.

In addition, see chains of the F0 subunit of this ATPase: atpF (B chain), HD0006; and atp6 (A chain), HD0004; and atpL (C chain), HD0005.

Blast Summary:  PSI-Blast Search
Numerous significant hits in gapped BLAST to atpG proteins; e.g., residues 1-288 are 73% similar to ATPG_HAEIN; residues 1-288 are 73% similar to the ATP synthase F1 gamma chain protein in Pasteurella multocida; and residues 1-288 are 68% similar to the ATP synthase subunit gamma in Salmonella typhimurium. BLAST reveals many similarities to other bacterial and eukaryotic ATPG sequences.



COGS Summary:  COGS Search
BeTs to 10 clades of COG0224
COG name: FoF1-type ATP synthase gamma subunit
Functional Class: C
The phylogenetic pattern of COG0224 is ----yQvcebrhujgp----x
Number of proteins in this genome belonging to this COG is 1

Blocks Summary:  Blocks Search
***** IPB000131 (ATP synthase gamma subunit) with a combined E-value of 3e-95.
    IPB000131A    4-35
    IPB000131B    73-97
    IPB000131C    118-128
    IPB000131D    166-191
    IPB000131E    233-285


ProDom Summary:  Protein Domain Search
Residues 2-288 are 73% similar to a (GAMMA SYNTHASE CHAIN HYDROLASE) protein domain (PD001150) which is seen in ATPG_HAEIN.



Paralogs:  Local Blast Search
HD0009 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 2 to 288 (E-value = 7.3e-157) place HD0009 in the ATP-synt family which is described as ATP synthase (PF00231)

PDB Hit:
pdb|1E1Q|G Chain G, Bovine Mitochondrial F1-Atpase At 100k >gi|... 104 2e-023
pdb|1MAB|G Chain G, Rat Liver F1-Atpase 102 5e-023

Gene Protein Sequence:
MAGAKEIRTKIASVRNTQKITKAMEMVATSKMRKTQERMAAGRPYSETIR
KVISHIAKGSIGYKHPFLIERDVKKVGYLVISTDRGLCGGLNINLFKTTL
NEFKAWKDKDVSVELGLVGSKGVSFYQSIGLKVRAHITGLGDSPEMERIV
GAVNEMINAYRNGEVDMVCIAYNRFENTMSQKTVIAQLLPLPKLENDELE
TKCSWDYLYEPNPQVLLDSLLIRYLETQVYQAVVDNLASEQAARMVAMKA
ATDNAGALIDELQLVYNKARQASITNELNEIVAGAAAI$

Gene Nucleotide Sequence:  Sequence Viewer
ATGGCAGGTGCTAAAGAGATTAGAACCAAAATTGCAAGTGTTCGTAATAC
GCAAAAAATTACGAAAGCAATGGAAATGGTGGCTACCTCTAAAATGCGTA
AAACGCAAGAGCGTATGGCAGCAGGTCGTCCATATTCAGAGACGATCCGT
AAAGTAATTAGCCATATCGCAAAAGGAAGCATTGGTTATAAGCACCCGTT
TTTAATTGAGCGTGATGTTAAAAAAGTAGGCTATTTAGTTATCTCTACCG
ACCGCGGTTTATGTGGCGGTCTTAATATCAATTTATTCAAGACAACCTTG
AATGAATTTAAAGCGTGGAAAGATAAAGACGTCAGTGTTGAACTTGGCTT
AGTAGGCTCAAAGGGAGTAAGCTTTTACCAATCTATTGGCTTAAAAGTTA
GGGCTCATATTACAGGTTTAGGTGATTCACCTGAAATGGAACGTATTGTT
GGTGCAGTTAATGAAATGATTAATGCTTATCGCAATGGTGAAGTGGATAT
GGTTTGTATTGCTTATAATCGTTTTGAAAATACAATGTCACAAAAAACAG
TTATTGCACAATTACTACCGTTACCTAAATTAGAAAATGATGAATTAGAA
ACAAAATGTTCTTGGGATTATCTCTACGAGCCTAACCCACAAGTATTATT
GGATAGTTTACTTATTCGTTATTTAGAAACACAGGTATATCAAGCAGTTG
TCGATAACCTTGCTTCTGAACAAGCCGCTCGAATGGTAGCAATGAAGGCC
GCAACAGATAATGCGGGAGCATTAATTGATGAGTTACAATTAGTGTATAA
CAAAGCTCGTCAAGCAAGTATTACAAATGAATTAAATGAAATTGTTGCAG
GTGCTGCTGCAATTTAA


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