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Chlamydia pneumoniae Search Results

Record: 1 of 1  
MiniMap IGR585 IGR581 IGR580 IGR583 IGR584 IGR586 IGR582 rs4, - CPn0733 udk, - CPn0735 CPn0729 mviN, - CPn0730 CPn0736 CPn0728 CPn0731 end4, - CPn0732 CPn0734 rs4, - CPn0733 udk, - CPn0735 CPn0729 mviN, - CPn0730 CPn0736 CPn0728 CPn0731 end4, - CPn0732 CPn0734 rs4, - CPn0733 udk, - CPn0735 CPn0729 mviN, - CPn0730 CPn0736 CPn0728 CPn0731 end4, - CPn0732 CPn0734
* Calculated from Protein Sequence

Gene ID: CPn0732

DNA Molecule Name:
1  

Genbank ID:


Gene Name:
end4  

Definition:
endonuclease IV

Gene Start:
822098

Gene Stop:
822979

Gene Length:
882

Molecular Weight*:
32375

pI*:
5.30

Net Charge*:
-6.73

EC:
3.1.21.2  

Functional Class:
DNA metabolism  

Pathway: pathway table

Comment:

DNA repair at the AP sites is initiated by
specific endonuclease cleavage of the
phosphodiester backbone. Such endonucleases are
also generally capable of removing blocking
groups from the 3'terminus of DNA strand breaks.

From Prosite PDOC00599:

DNA damaging agents such as the antitumor drugs
bleomycin and neocarzinostatin or those that
generate oxygen radicals produce a variety of
lesions in DNA. Amongst these is base-loss which
forms apurinic/apyrimidinic (AP) sites or strand
breaks with atypical 3'termini. DNA repair at the
AP sites is initiated by specific endonuclease
cleavage of the phosphodiester backbone. Such
endonucleases are also generally capable of
removing blocking groups from the 3'terminus of
DNA strand breaks.

AP endonucleases can be classified into two
families on the basis of sequence similarity.
What we call family 2 groups the enzymes listed
below.

- Bacterial endonuclease IV (EC 3.1.21.2) (gene
nfo).
- Mycobacterium leprae probable endonuclease
(gene end).
- Yeast apurinic endonuclase APN1 (EC 4.2.99.18).

- Caenorhabditis elegans hypothetical protein
T05H10.2.

Blast Summary:  PSI-Blast Search
CPn0732 is similar to UU306 in U. urealyticum
and MG235 in M. genitalium, both predicted
endonuclease IV.

CPn0732 is orthologously related to CT625, a predicted endonuclease.
Residues 1-286 are 71% similar to CT625.

COGS Summary:  COGS Search
BeTs to 11 clades of COG0648
COG name: Endonuclease IV
Functional Class:  L
The phylogenetic pattern of COG0648 is -mtkyqv-ebr---gp--in-
Number of proteins in this genome belonging to this COG is 1

Blocks Summary:  Blocks Search


ProDom Summary:  Protein Domain Search


Paralogs:  Local Blast Search
No evidence of paralogs in C. pneumoniae.

Pfam Summary:  Pfam Search
Residues 12 to 247 (E-value = 1.4e-94) place CPn0732 in the AP_endonuc_2 family which is described as AP endonuclease family 2 (PF01261)

PDB Hit:


Gene Protein Sequence:
MKVLPPPSIPLLGAHTSTAGGLKNAIYEGRDIGASTVQIFTANQRQWQRR
ALKEEVIEDFKAALKETDLSYIMSHAGYLINPGAPDPVILEKSRIGIYQE
ILDCITLGISFVNFHPGAALKSSKEDCMNKIVSSFSQSAPLFDSSPPLVV
LLETTAGQGTLIGSNFEELGYLVQNLKNQIPIGVCVDTCHIFAAGYDITS
PQGWEDVLNEFDEYVGLSYLRAFHLNDSMFPLGANKDRHAPLGEGYIGKE
SFKFLMTDERTRKIPKYLETPGGPENWQKEIGELLKFSKNRDS$

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAAGTACTTCCTCCTCCCTCCATTCCCTTACTAGGGGCTCACACTTC
AACTGCTGGTGGACTCAAAAATGCGATTTATGAAGGCCGGGATATAGGGG
CTTCTACAGTTCAGATTTTTACAGCAAACCAAAGGCAGTGGCAAAGACGG
GCTCTAAAAGAAGAAGTGATTGAAGATTTCAAAGCAGCGCTCAAAGAAAC
TGACCTTTCTTATATTATGAGTCATGCAGGATATCTGATTAATCCAGGAG
CCCCTGATCCGGTAATTTTAGAAAAAAGTCGGATTGGCATTTATCAAGAA
ATTCTGGACTGCATCACTTTAGGCATTTCTTTTGTTAATTTTCACCCTGG
AGCAGCTCTCAAAAGCTCTAAAGAAGACTGCATGAATAAAATTGTCAGCA
GTTTTAGCCAATCGGCCCCTTTATTTGATAGTTCTCCTCCTCTTGTTGTT
TTACTGGAAACCACAGCGGGTCAGGGAACGTTAATTGGGAGTAACTTTGA
AGAATTGGGTTACCTCGTTCAGAATTTGAAAAATCAAATTCCCATTGGCG
TGTGTGTAGATACTTGTCATATTTTTGCTGCGGGGTACGACATTACCTCT
CCACAGGGGTGGGAAGATGTTCTTAATGAATTTGACGAGTATGTCGGTTT
ATCTTATCTACGAGCCTTTCATCTCAATGATTCTATGTTTCCATTAGGAG
CGAACAAAGACCGCCATGCGCCCCTTGGAGAGGGCTATATAGGTAAGGAA
TCTTTTAAATTTTTAATGACAGATGAACGAACTAGAAAAATTCCTAAGTA
TTTAGAAACCCCTGGTGGGCCTGAAAATTGGCAAAAAGAAATTGGGGAAC
TTTTGAAGTTTTCAAAAAACAGAGATAGTTAG


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