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Chlamydia trachomatis Search Results

Record: 1 of 1  
MiniMap IGR154 IGR156 IGR155 IGR157 IGR153 IGR152 tdk, - CT188 dnaX,dnaZ, - CT187 gyrB, - CT190 gyrA, - CT189 devB,zwf,nagB, - CT186 zwf, - CT185 pyrG, - CT183 tdk, - CT188 dnaX,dnaZ, - CT187 gyrB, - CT190 gyrA, - CT189 devB,zwf,nagB, - CT186 zwf, - CT185 pyrG, - CT183 tdk, - CT188 dnaX,dnaZ, - CT187 gyrB, - CT190 gyrA, - CT189 devB,zwf,nagB, - CT186 zwf, - CT185 pyrG, - CT183 yqgF, - CT184 yqgF, - CT184
* Calculated from Protein Sequence

Gene ID: CT188

DNA Molecule Name:
1  

Genbank ID:


Gene Name:
tdk  

Definition:
thymidylate kinase (DTMP)

Gene Start:
210410

Gene Stop:
209802

Gene Length:
609

Molecular Weight*:
22425

pI*:
7.56

Net Charge*:
1.11

EC:
2.7.4.9  

Functional Class:
purines, pyrimidines, nucleosides and nucleotides; pyrimidines  

Pathway: pathway table
Nucleotide Metabolism; Pyrimidine metabolism

Comment:
In B.subtilis, this enzyme phosphorylates dTMP to form dTDP.

Blast Summary:  PSI-Blast Search
Numerous hits using gapped BLAST to thymidylate kinase sequences, e.g.,
residues 1-184 are 38% similar to KTHY_BACSU. Residues 2-185 are 29% similar to TP0354 of T.pallidum,
a predicted thymidylate kinase. CT188 is also similar to MG006 of M.genitalium.

CT188 is orthologously related to CPn0273: residues 1-197 are 56%
similar to CPn0273.

COGS Summary:  COGS Search
BeTs to 17 clades of COG0125
COG name: Thymidylate kinase
Functional Class:  F
The phylogenetic pattern of COG0125 is AmTkyqvceBrhujgpolinx
Number of proteins in this genome belonging to this COG is 1


Blocks Summary:  Blocks Search
None.

ProDom Summary:  Protein Domain Search
Closest domain seen in KTHY_BACSU: 41% similarity over residues 1-143
of CT188.

Paralogs:  Local Blast Search
No evidence of paralogs in C. trachomatis.

Pfam Summary:  Pfam Search
Residues 5 to 195 (E-value = 1.4e-83) place CT188 in the Thymidylate_kin family which is described as Thymidylate kinase (PF02223)

PDB Hit:
none

Gene Protein Sequence:
MFIVVEGGEGAGKTQFIQALSKRLIEEGREIVTTREPGGCSLGDSVRGLL
LDPEQKISPYAELLLFLAARAQHIQEKIIPALKSGKTVISDRFHDSTIVY
QGIAGGLGESFVTNLCYHVVGDKPFLPDITFLLDIPAREGLLRKARQKHL
DKFEQKPQIFHRSVREGFLALAEKAPDRYKVLDALLPTEASVDQALLQIR
ALI

Gene Nucleotide Sequence:  Sequence Viewer
GTGTTTATTGTAGTAGAAGGCGGAGAAGGTGCTGGGAAAACTCAGTTTAT
ACAAGCACTTTCTAAGCGTTTAATAGAAGAAGGCAGAGAAATTGTCACTA
CGAGAGAGCCAGGGGGATGCTCTCTTGGAGACAGTGTTCGAGGCCTTCTT
CTGGATCCAGAACAAAAAATATCTCCATATGCAGAATTGTTGTTGTTTTT
AGCAGCTCGTGCACAACACATTCAGGAAAAGATCATACCTGCTCTTAAGT
CTGGGAAGACGGTTATAAGCGATCGTTTTCACGATTCTACTATTGTATAT
CAAGGAATTGCTGGAGGCTTAGGGGAGAGTTTTGTTACGAACTTATGTTA
TCATGTTGTGGGAGATAAGCCGTTCTTGCCAGACATCACATTCTTATTGG
ATATCCCAGCAAGAGAAGGATTACTACGAAAGGCTCGTCAGAAACATCTG
GATAAATTTGAGCAAAAACCACAAATTTTCCACCGGTCTGTCAGAGAAGG
ATTTCTTGCTTTAGCAGAAAAAGCTCCAGATAGGTACAAGGTTTTAGATG
CCCTCTTGCCAACAGAGGCTTCTGTTGACCAAGCTCTCTTACAGATTCGT
GCATTGATA


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